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| Adult-onset Still's disease ： ウィキペディア英語版 |
Adult-onset Still's disease
Adult-onset Still's disease (AOSD) is a rare systemic inflammatory disease characterized by the classic triad of persistent high spiking fevers, joint pain and a distinctive salmon-colored bumpy rash. The disease is considered a diagnosis of exclusion.〔 Levels of the iron-binding protein ferritin may be elevated with this disorder. AOSD may present in a similar manner to other inflammatory diseases and to autoimmune diseases, which must be ruled out before making the diagnosis. Prognosis is usually favorable but manifestations of the disease affecting the lungs, heart, or kidney may occasionally cause severe life-threatening complications.〔 It is treated first with steroids such as prednisone. Drugs that block the action of interleukin-1, particularly IL-1β, are effective treatments.
== Signs and symptoms==
The disease typically presents with joint pain, high fevers, a salmon-pink rash, enlargement of the liver and spleen, swollen lymph nodes, and an increased white blood cell count in the blood. Tests for rheumatoid factor and anti-nuclear antibodies are usually negative and serum ferritin is elevated. Patients experiencing a flare-up from Adult-onset Still's disease usually report extreme fatigue, swelling of the lymph nodes, and less commonly fluid accumulation in the lungs and heart. In rare cases, AOSD can cause aseptic meningitis and sensorineural hearing loss.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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